Patient measurements
Projected outcomes
Sorted by average % total body weight loss
- GLP-1
Liraglutide (Saxenda)
8.0% TBWL · 56 weeks · SCALE trial
−17.6 lb−8.0 kg · BMI → 32.7Projected weight: 202.4 lb (91.8 kg) - GLP-1
Semaglutide (Wegovy)
14.9% TBWL · 68 weeks · STEP 1
−32.8 lb−14.9 kg · BMI → 30.2Projected weight: 187.2 lb (84.9 kg) - Endoscopic
Endoscopic Sleeve Gastroplasty (ESG)
15.0% TBWL · 12 months · MERIT RCT
−33.0 lb−15.0 kg · BMI → 30.2Projected weight: 187.0 lb (84.8 kg) - GLP-1
Tirzepatide (Zepbound)
20.9% TBWL · 72 weeks · SURMOUNT-1 (15 mg)
−46.0 lb−20.9 kg · BMI → 28.1Projected weight: 174.0 lb (78.9 kg) - GLP-1
Retatrutide (investigational)
24.2% TBWL · 48 weeks · Phase 2 (12 mg)
−53.2 lb−24.1 kg · BMI → 26.9Projected weight: 166.8 lb (75.6 kg) - Bariatric Surgery
Sleeve Gastrectomy
28.0% TBWL · 12–24 months · Pooled outcomes
−61.6 lb−27.9 kg · BMI → 25.6Projected weight: 158.4 lb (71.8 kg) - Bariatric Surgery
Roux-en-Y Gastric Bypass
32.0% TBWL · 12–24 months · Pooled outcomes
−70.4 lb−31.9 kg · BMI → 24.1Projected weight: 149.6 lb (67.9 kg) - Bariatric Surgery
One Anastomosis Gastric Bypass (OAGB)
34.0% TBWL · 12–24 months · YOMEGA & meta-analyses
−74.8 lb−33.9 kg · BMI → 23.4Projected weight: 145.2 lb (65.9 kg) - Bariatric Surgery
SADI-S
37.0% TBWL · 12–24 months · IFSO position statement
−81.4 lb−36.9 kg · BMI → 22.4Projected weight: 138.6 lb (62.9 kg) - Bariatric Surgery
Biliopancreatic Diversion w/ Duodenal Switch
40.0% TBWL · 12–24 months · Long-term cohorts
−88.0 lb−39.9 kg · BMI → 21.3Projected weight: 132.0 lb (59.9 kg)
Important
Projections use average % total body weight loss reported in clinical trials and meta-analyses. Individual outcomes vary substantially based on adherence, comorbidities, metabolic factors, and operative technique. This tool is for educational discussion only and is not a substitute for clinical judgment.